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Gamers Unlock Protein Mystery That Baffled AIDS Researchers For Years
Brenelael
Member UncommonPosts: 3,821
Gamers Unlock Protein Mystery That Baffled AIDS Researchers For Years
September 19, 2011 10:42am EST
In just three weeks, gamers deciphered the structure of a key protein in the development of AIDS that has stumped scientists for years. According to a study published Sunday in the journal Nature Structural & Molecular Biology, the findings could present a significant breakthrough for AIDS and HIV research.
Using an online game called Foldit, players were able to predict the structure of a protein called retroviral protease, an enzyme that plays a critical role in the way HIV multiplies. Unlocking the build of the protein could theoretically aid scientists in developing drugs that would stop protease from spreading.
“Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein,” the study reads. “Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.”
Developed by researchers at the University of Washington, Foldit turns scientific problems into competitive games. Players were charged with using spatial and critical thinking skills to build 3D models of protease. Few of these players had any kind of background in biochemistry.
According to Fox, it took players a matter of days to come up with models that were solid enough for researchers to translate into scientific rendering of the protein.
“People have spatial reasoning skills, something computers are not yet good at,” Foldit’s lead designer Seth Cooper said in a statement. “Games provide a framework for bringing together the strengths of computers and humans.”
Foldit has not only made this breakthrough with AIDS research, but it has also aided in Cancer and Alzheimer’s research. For more, read the study in its entirety here.
For more from Leslie, follow her on Twitter @LesHorn.
Gamers helping medical science... Interesting.
Bren
while(horse==dead)
{
beat();
}
Comments
Yet people (women) will still write off gaming as wasted potential.
Don't underestimate the hardcore gamers
I mean, we've had people DIE from playing nonstop.
"I have only two out of my company and 20 out of some other company. We need support, but it is almost suicide to try to get it here as we are swept by machine gun fire and a constant barrage is on us. I have no one on my left and only a few on my right. I will hold." (First Lieutenant Clifton B. Cates, US Marine Corps, Soissons, 19 July 1918)
When they aren't playing Farmville on facebook... LOL
Bren
while(horse==dead)
{
beat();
}
lol
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