Depends on what you mean by "alot of populations". Eve is the largest sci fi mmorpg, and regularly facilitates simultaneous interactions between greater numbers of players than any other mmo by far. So, you won't find another "galaxy game" with a population comparable to Eve.
If, on the other hand, you're looking for a game that takes place in space with other players with enough activity to feel like there are plenty of opportunities and stuff happening all the time, there are a few. You'll even find one that has been continuously running as long as Eve.
"The simple is the seal of the true and beauty is the splendor of truth" -Subrahmanyan Chandrasekhar Authored 139 missions in VendettaOnline and 6 tracks in Distance
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If, on the other hand, you're looking for a game that takes place in space with other players with enough activity to feel like there are plenty of opportunities and stuff happening all the time, there are a few. You'll even find one that has been continuously running as long as Eve.
"The simple is the seal of the true and beauty is the splendor of truth" -Subrahmanyan Chandrasekhar
Authored 139 missions in Vendetta Online and 6 tracks in Distance